Cellular Neurobiology Research Group

We are interested in the functional analysis of intracellular transport mechanisms and have identified novel protein families participating in these processes, the PACSIN and the EHD protein family. Individual members of these families are involved in endocytosis, recycling and secretion of distinct cargoes via vesicles or tubular structures. Another aspect of our research involves investigations on changes of these processes in neurodegenerative diseases with focus on the neurospecific family members.

PACSIN protein family

The three members of the PACSIN protein family, also named syndapin and FAP52 participate in rearrangements of actin networks during endocytic, recycling and secretory processes. In contrast to the neuron-specific PACSIN 1, other members of the PACSIN protein family display a broader tissue distribution. PACSIN proteins bind via their C-terminal SH3 domains to proline-rich domains of several proteins.

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EHD protein family

The EHD proteins, originally named HPAST/PfPast-1, EHD1 also named RME-1, and EHD4 also named Pincher, are a family of proteins independently found by several groups and distantly related to sarcalumenin and its splice form 53K glycoprotein. All members of this family comprise three regions: a well conserved N-terminal G-domain including a nucleotide-binding P-loop motif, a central non-conserved linker region, and a conserved C-terminal Eps15-homology (EH) domain.

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